ActiScreen™XL-FDP

ActiScreen ™ XL-FDP uses latex beads coupled to the highly specific DD3B6 / 22 monoclonal antibody. XL-FDP present in plasma binds to the antibody coated latex beads resulting in clumping, visible on the map test, when the XL-FDP concentration is greater than the lower limit of detection of the test.

D-dimer is a degradation product of crosslinked fibrin (XL-FDP) by plasmin, the main clot lysis enzyme. These are small fragments of reticulated fibrin circulating in the blood, a marker of fibrinolysis.
Measuring the level of D-dimer in a patient is useful in indicating the presence of a blood clot.
Therefore, levels below predetermined thresholds can be used to rule out conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke. A D-dimer level can be used to help diagnose disseminated intravascular coagulation (DIC) and to monitor the effectiveness of treatment for DIC.