HEMOSTASIS COAGULATION ROUTINE REAGENTS THROMBOPHILIA FACTOR V LEIDEN / APCR
APC Resistance Kit
Determination of resistance to protein C activated by the coagulant method.
The APC Resistance Kit is a functional plasma coagulation test that differs from other functional tests for resistance to APC by acting specifically at the prothrombinase complex.
It is based on an FV-dependent prothrombin activator isolated from snake venom.
The strength and specificity of the test are improved by eliminating possible disturbances by factors upstream of the coagulation cascade and calcium independence.
Advantages
- Vials suitable for hemostasis analyzers
- Protocols are available on request
- Excellent stability on board hemostasis analyzers
- Excellent linearity over a large measurement area
Informations
Resistance to activated protein C is an anomaly described by Dahlbäck in 1993.
Bertina discovered in 1994 the presence of a mutation in the factor V (FV) gene.
This mutation leads to the replacement at position 506 of an arginine by a glutamine (Arg506Gln), which affects one of the sites of cleavage of FV by PCa. As a result, FV "resists" inactivation by PCa.
The mutated FV is referred to as FV Leiden. This factor V loses its function as a cofactor of the protein C system, that is to say of a system which inhibits coagulation; on the other hand, it retains its procoagulant properties. There are other cases of mutations related to the resistance of activated protein C.
Documentation
Download the product sheetPrice list, safety data sheets and notices are accessible to our registered customers.
Chronometric assay
References
| 4-5344510 | Kit | 3 x 40 tests |
