HEMOSTASIS COAGULATION RESEARCH REAGENTS VENOM PROTEASES CROTALUS DURISSUS TERRIFICUS VENOM SNAKE
Convulxin
Product derived from the venom of Crotalus durissus terrificus in freeze-dried form.
Molecular weight (Da) : 84 000
Convulxin (CVX), a potent platelet aggregation protein belonging to the C-type heterodimeric lectin family, is isolated from the venom of the snake Crotalus durissus terrificus. Neither antibodies against GPIb nor against echicetin had any effect on convulxin-induced platelet aggregation, demonstrating that, unlike other venom C-type lectins acting on platelets, GPIb is not not involved in convulxin-induced platelet activation.
Convulxin activates mammalian platelets via binding to the platelet collagen receptor p62/GPVI and clustering of glycoprotein VI (GPVI) receptors under physiological conditions.
GPVI occupancy and clustering activates Src family kinases, phosphorylating the Fc receptor γ chain and activating p72SYK which is critical for downstream activation of platelets.
Allows the study of platelet receptors.
Advantages
The venom proteases offered are highly purified, homogenous preparations with the indicated activities.
Informations
Snake venom proteases are useful tools for studying coagulation reactions. Venoms contain more than 20 different compounds, mostly proteins and polypeptides. Some of the proteins in snake venom have very specific effects on various biological functions including blood coagulation, blood pressure regulation, transmission of the nervous or muscular impulse and have been developed for use as diagnostic tools. Plasma coagulation Factors are usually inactive and require proteolytic activation as a first step towards a chronometric or colorimetric assay. It is often advantageous to use specific enzymes from snake venoms to activate coagulation Factors rather than physiological activators. In contrast to other activators, many snake venom enzymes are not dependent from cofactors, phospholipid or calcium ions.
Documentation
Download the product sheetPrice list, safety data sheets and notices are accessible to our registered customers.
References
| 6-VEN-CONV-50 | Vial | 50 µg |
