HEMOSTASIS COAGULATION RESEARCH REAGENTS VENOM PROTEASES ECHIS CARINATUS VENOM SNAKE
Ecarin 50 EU
Product derived from Echis carinatus venom in lyophilized form.
MW (Da) : 55 000 à 60 000
Ecarin is a snake (Echis carinatus) venom that directly activates prothrombin to meizothrombin. The use of the measurement of the coagulation time by ecarin allows the biological monitoring of the anticoagulant by hirudin. The meizothrombin can then bind stoichiometrically to the hirudin to be assayed.
Advantages
The proposed venom proteases are obtained from highly purified homogeneous preparations with indication of the activities.
Informations
Snake venom proteases are interesting tools for studying coagulation reactions. Venoms contain more than 20 different compounds, mainly proteins and polypeptides. Some snake venoms have very specific effects on various biological functions, including blood clotting, regulation of blood pressure, transmission of nerve or muscle impulses.
They were developed for use as diagnostic tools. Plasma coagulation factors are usually inactive and require proteolytic activation as a first step towards a chronometric or colorimetric assay. It is often advantageous to use specific enzymes from snake venoms to activate coagulation factors rather than using physiological activators. In contrast to other activators, many snake venom enzymes are not dependent on cofactors, phospholipids, or calcium ions.
Documentation
Download the product sheetPrice list, safety data sheets and notices are accessible to our registered customers.
References
| 8-116-01 | Vial | 1 x 50 U |
