HEMOSTASIS COAGULATION RESEARCH REAGENTS DEFICIENT PLASMAS CONGENITAL DEFICIENT PLASMAS (KITS)
Human Factor VIII congenital Deficient Plasma with inhibitor
Native coagulation factor deficient plasmas are fresh frozen plasmas obtained exclusively from donors with severe congenital clotting factor deficiency and exhibiting anti-FVIII inhibitory antibodies.
These native coagulation factor-deficient plasmas are recommended for the evaluation of the activity of coagulation factors by the method of assaying the level of prothrombin (PT) or activated partial thromboplastin time (TCA) requiring the use of a plasma lacking in factor (<1%) in hemostasis.
Advantages
- No additives or preservatives.
- Freezing the plasmas makes it possible to keep the matrix perfectly intact and to avoid reconstitution.
- Packaging in plastic cryotubes suitable for all STA-R type micro-cup supports.
Information
Factor VIII is a glycoprotein mainly synthesized by the liver. It circulates in the plasma in the form bound to VWF which protects it from rapid proteolytic degradation. It is activated by FXa or thrombin in FVIIIa which will complex with FIXa in the presence of phospholipids to activate FX in FXa.
A patient who is deficient in FVIII has hemophilia A. The occurrence of anti-FVIII inhibitory antibodies represents the major complication of replacement therapy with FVIII concentrates in hemophiliacs A.
There is therefore an autoimmunization responsible for acquired hemophilia.
Documentation
Download the product sheetPrice list, safety data sheets and notices are accessible to our registered customers.
Fresh frozen plasmas
References
| 7-1800 | Kit | 5 x 1.0 mL |
