Human vitronectin

 
Formulation : 50 mM sodium phosphate; 150 mM NaCl, pH 7.4

MW(Da) : 75 000 (single chain form) 10 and 65 kda double chain form
Extinction coefficient: 13.8
Isoelectric point: 4.75 - 5.25
Structure: circular shape if monomeric or dimeric and possibility in oligomeric form.
Monomer: 459 amino acids, single chain polypeptide with 7 intrachain disulfide bonds and 1 free sulfhydryl.


Advantages

The vast majority of plasma derivatives is pure (without additives) with > 95 % purity SDS-PAGE.
Expiration date of one year from delivery.
Delivery in large quantities.
Discount according to quantities.


Informations

Vitronectin (Vn) is an adhesive glycoprotein, synthesized by the liver, released in plasma and present in the extracellular matrix. Vn binds PAI-1. This complex fully activates PAI-1, unlike PAI-1 in solution, where it does not appear to be stable and inactive. Vn therefore seems to regulate the enzymatic specificity of PAI-1, by stabilizing it. Decreased Vn levels occur in DICs and liver disease (cirrhosis). Vn deposition is associated with atherosclerotic lesions.


Documentation

Download the product sheet
Price list, safety data sheets and notices are accessible to our registered customers.


 
 
congeleRUObioHazardstockage_-70Cimportateurdistributeur
 

References

9-HVN-0230Vial100 µg
9-HVN-0230-1Vial1 mg

Related products: 1