HEMOSTASIS COAGULATION RESEARCH REAGENTS VENOM PROTEASES AGKISTRODON CONTORTRIX VENOM SNAKE
Protac® 3U
Product derived from Agkistrodon venom contortrix in freeze-dried form.
MW (Da): 36,000 to 42,000
CAS: 103469-93-8
The Protac®, a single-chain glycoprotein, is a fast-acting activator of protein C, isolated from the venom of the copper-headed snake Agkistrodon contortrix. It rapidly converts human C protein and other vertebrates into activated C protein that can be determined, either by measuring its effect on the extension of an activated cephalin time (TCA) by measuring its enzymatic activity using a specific chromogenic substrate. Protac is therefore used to determine the levels of C protein and S protein in plasma.
Advantages
The venom proteases offered are highly purified, homogenous preparations with the indicated activities.
Informations
Snake venom proteases are useful tools for studying coagulation reactions. Venoms contain more than 20 different compounds, mostly proteins and polypeptides. Some of the proteins in snake venom have very specific effects on various biological functions including blood coagulation, blood pressure regulation, transmission of the nervous or muscular impulse and have been developed for use as diagnostic tools. Plasma coagulation Factors are usually inactive and require proteolytic activation as a first step towards a chronometric or colorimetric assay. It is often advantageous to use specific enzymes from snake venoms to activate coagulation Factors rather than physiological activators. In contrast to other activators, many snake venom enzymes are not dependent from cofactors, phospholipid or calcium ions.
Documentation
Download the product sheetPrice list, safety data sheets and notices are accessible to our registered customers.
References
| 8-113-01 | Vial | 1 x 3 U |
