HEMOSTASIS COAGULATION RESEARCH REAGENTS VENOM PROTEASES VIPERA RUSSELII VENOM
RVV-Facteur V Activator
Product derived from the venom of Vipera russelli in lyophilized form.
MW (Da) : 28 000
RVV-V is a specific activator of FV to FVa from Russell's viper venom which converts single chain FV into an active 2 chain compound. Activated FV is not stable and loses activity within 20 hours at 37 ° C.
Therefore, RVV-V is also used to selectively inactivate FV in plasma in order to prepare a routine reagent for determination of FV.
Advantages
Venom proteases are obtained from highly purified homogeneous preparations with indication of the activities.
Informations
Snake venom proteases are interesting tools for studying coagulation reactions. Venoms contain more than 20 different compounds, mainly proteins and polypeptides. Some snake venoms have very specific effects on various biological functions, including blood clotting, regulation of blood pressure, transmission of nerve or muscle impulses.
They were developed for use as diagnostic tools. Plasma coagulation factors are usually inactive and require proteolytic activation as a first step towards a chronometric or colorimetric assay. It is often advantageous to use specific enzymes from snake venoms to activate coagulation factors rather than using physiological activators. In contrast to other activators, many snake venom enzymes are not dependent on cofactors, phospholipids, or calcium ions.
Documentation
Download the product sheetPrice list, safety data sheets and notices are accessible to our registered customers.
References
| 8-121-03 | Vial | 1 x 1000 U |
