HEMOSTASIS COAGULATION RESEARCH REAGENTS INHIBITORS NATURAL PROTEASE INHIBITORS
Human TAFI
Formulation : 20 mM HEPES, 150 mM NaCl, pH 7.4
Activity : 2.0 to 9.2 units/mg MW(Da) : 60 000 Extinction coef. : 14.9 (calculated by cDNA) Isoelectric point : 5.0 Structure : 92 amino acids single chain glycoprotein. N-terminal activation peptide, catalytic domain of 309 amino acids.
Advantages
Frozen product.
Expiry date 1 year.
Plastic tubes.
Discount according to quantities.
Informations
After activation by thrombin, the mature protein negatively regulates fibrinolysis by removing plasminogen binding sites to fibrin. TAFI (Thrombin Activatable Fibrinolysis Inhibitor) is a single chain glycoprotein synthesized by the liver and circulating at a plasma concentration of 50 nM. Thrombin cleaves the zymogen and releases the 92 amino acids activating peptide containing 4 N-glycosylation sites and the plamsinogen recognition site. TAFI plays an important role in the interaction between the fibrinolytic, anticoagulant and procoagulant systems.
Documentation
Download the product sheetPrice list, safety data sheets and notices are accessible to our registered customers.
References
| 9-TAFI-01 | Vial | 50 µg |
| 9-TAFI-01-1 | Vial | 1 mg |
